研究方向

分子内分泌和代谢调节的机理和应用研究（宋青）
LXR和FXR受体对酯类代谢的影响（宋青）
重组人新型复合α干扰素（I类新药）的载体构建（杜宏武）
功能蛋白的筛选和作用机理（杜宏武）
注射用重组人新型白介素-2（II 类新药）的构建（杜宏武）
人全基因组生物芯片构建及HL60细胞分化研究（杜宏武）
兴奋剂检测蛋白芯片关键技术及应用研究（杜宏武）
人B细胞刺激因子（BLyS）功能研究（杜宏武）
采用原核或真核微生物生产辅酶Q、叶黄素、虾青素和番茄红素等药物（闫海）
肿瘤诊断药物的研究（刘丽琴）
肿瘤靶向治疗药物和纳米药物载体的研究（刘丽琴）
苏云金芽孢杆菌生物农药的抗紫外辐射及发酵工程（邱丽娜）
以泛素-蛋白酶体系统为作用靶标的抗肿瘤药物设计与筛选（时国庆）

主要研究课题

1 北京市教委共建项目“利用细胞核受体开发治疗药物和保健产品”，经费：100万元。（宋青）
2 科技部中俄国际合作项目“预防和免疫治疗疫苗及其新型佐剂增强免疫功能的研究”，经费：30万元。(刘丽琴)
3 国家自然科学基金“新的hMGF相互作用蛋白的筛选和街道肌肉再生的分子机制”，经费：21万元。(杜宏武)
4 北京市科技新星项目“奥运会兴奋剂检测技术研究”，经费：30万元。(杜宏武)

代表性研究论文

1. Fukuchi J, Song C, Hiipakka, RA, Liao S., J. Steroid Biochem Mol. Biol. 2005. 5beta-Cholane activators of the farnesol x receptor..
2. Fukuchi J, Song C, Ko AL, Liao S., Steroids. 2003 Sep;68(7-8):685-91.Transcriptional regulation of farnesyl pyrophosphate synthase by liver X receptors.
3. Peng D, Song C, Reardon CA, Liao S, Getz GS., J Neurochem. 2003 Sep;86(6):1391-402. Lipoproteins produced by ApoE-/- astrocytes infected with adenovirus expressing human ApoE.
4. Song C, Liao S., Steroids. 2001 Sep;66(9):673-81. Hypolipidemic effects of selective liver X receptor alpha agonists.
5. Song C, Hiipakka RA, Liao S., Steroids. 2001 Jun;66(6):473-9. Auto-oxidized cholesterol sulfates are antagonistic ligands of liver X receptors: implications for the development and treatment of atherosclerosis.
6. Song C, Liao S., Endocrinology. 2000 Nov;141(11):4180-4. Cholestenoic acid is a naturally occurring ligand for liver X receptor alpha.
7. Song C, Hiipakka RA, Liao S., Steroids. 2000 Aug;65(8):423-7. Selective activation of liver X receptor alpha by 6alpha-hydroxy bile acids and analogs.
8. Song C, Hiipakka RA, Kokontis JM, Liao S., Ann N Y Acad Sci. 1995 Jun 12;761:38-49. Ubiquitous receptor: structures, immunocytochemical localization, and modulation of gene activation by receptors for retinoic acids and thyroid hormones.
9.Du H, Wu M, Yang W, Yuan G, Sun Y, Lu Y, Zhao S, Du Q, Wang J, Yang S, Pan M, Lu Y, Wang S, Cheng J. Development of miniaturized immunoassays on a protein chip as a creening tool for drugs. Clinical Chemistry. 2005, 51: 368-375.
10.Du H, Lu Y, Wu M, Wang J, Zhao S, Pan M, Cheng J. Preparation of Steroid Antibodies and Parallel Detection of Multianabolic Steroid Abuse with Conjugated Hapten Microarray. Analytical Chemistry. 2004, 76：6166-6171.
11.Du H, Yang W, Xing W, Su Y, Cheng J. Parallel detection and quantitation of nine immunosaaays using a protein microarray in serum. Biomedical Microdevices. 2005, 76: 2-5.
12.Chen G, Du H, Peng S, Xu D, Wang J. Construction and direct immunization of eukaryotic expression plasmid encoding human soluble B-cell activating factor. Frontiers Bioscience. 2006, 11: 121-125.
13.Chen G, Du H, Zhang Z, Peng S, Xu D, Wang J. Primary immune effects of eukaryotic expression plasmids encoding two hyperactive mutants of human soluble B lymphocyte stimulator. Journal Clinical Immunology. 2005, 25: 444-450.
14.Du H and Cheng J. Protein chips for high-throughput drug screening in athletes. Expert Review Proteomics. 2006, 3;111-114.
15.Chen G, Du H, Peng S, Xu D, Wang J. Development of an immunoassay kit for detecting the alteration of serum B cell activating factor in thermally injured mice. Molecular Cellular Biochemistry. 2006, 281: 185-188.
16. Such-Sanmartín G, Bosch J, Segura J, Wu M, Du H, Chen G, Wang S, Vila-Perelló M, Andreu D, Gutiérrez-Gallego R. Characterisation of the 5 kDa growth hormone isoform. . 2008; 26:152-162.
17.Liu L, Guo H,Tang Z, Lu J, Wang X. Preparation, Charcterization and Biodistribution of a New Techenetium-99m Complex With HYNIC(tricine)-AMDP. J. Label Compd Radiopharm. 2005, 48:S254.
18.Liu L, Wang X. Prepartion, Charcterization and Biodistribution of 99mTc-EDP As a New Bone Imaging Agent. J. Label Compd Radiopharm. 2005, 48:S259.
19.Liu L, Wang X. The study of 99mTc-MOEDP As a New Bone Imaging Agent. J. Label Compd Radiopharm. 2005, 48:S256.